Multiple sclerosis is a lifelong, potentially disabling disease of the central nervous system that affects the white matter tracts of the central nervous system in a sporadic and unpredictable manner. The disease produces inflammation and demyelination of the white matter, as well as varying amounts of damage and destruction to the underlying axon. The onset of disease is most often in early adulthood. Individuals experience a myriad of symptoms with likely progression of disability over time.
Symptoms may include fatigue, visual disturbances, sensory changes, incoordination, pain, tremor, elimination dysfunction, and cognitive impairment. Symptoms usually occur as relapses early in the disease, or as symptoms that appear over 24–48 hours and recede to some extent
over weeks to months. After a decade or so, many individuals experience fewer relapses, but in their place is a slow progression of MS symptoms that often leads to increased functional disability over time. A small percentageof patients will experience progression from the onset of the disease and experience progressive mobility impairment over time.
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